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Category:
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Ion Channels Other Channel Modulators
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Cat.No.
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Product Name
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2625 |
Zonisamide
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| Alternative name(s): |
AD
810 |
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CI
912 |
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Price and Availability
Click here for full price details of
Zonisamide
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Chemical Name:
1,2-Benzisoxazole-3-methanesulfonamide |
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Biological Activity:
Antiepileptic,
possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks
voltage-sensitive Na+ and T-type Ca2+ channels,
stimulates BKCa channels, modulates GABA, glutamate and monoamine
neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and
nitric oxide free radicals. Displays neuroprotective and antiParkinsonian
activity.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Tokumaru et al
(2000) In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in
rats. Neurochem.Res. 25 1107. Sobieszek et al
(2003) Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol. 55
683. Gluck et al (2004) Novel dopamine releasing response of an
anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm.
111 713. Huang et al (2007) Activation by
Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated
potassium channel in differentiated hippocampal neuron-derived H19-7 cells.
J.Pharmacol.Exp.Ther. 321 98.
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Keywords: Zonisamide, Other Channel Modulators, Blocks Voltage-sensitive Na+ & T-type Ca2+ Channels; Anticonvulsant, AD 810, CI 912, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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