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Category:
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Transporters Ion Pumps/Transporters
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Cat.No.
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Product Name
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2727 |
Zoniporide dihydrochloride
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| Alternative name(s): |
CP-597,396 |
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Price and Availability
Click here for full price details of
Zoniporide
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Chemical Name:
[1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl
]guanidine dihydrochloride |
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Biological Activity:
Sodium-hydrogen exchanger isoform-1 (NHE-1)
inhibitor that displays selectivity over other NHE isoforms (Ki
values are 14, 2200, and 220000 nM for human NHE-1, human NHE-2 and rat NHE-3
respectively). Inhibits NHE-1 dependent 22Na+ uptake in
vitro (IC50 = 14 nM) and provides cardioprotection from myocardial
ischaemic injury in vivo (EC50 = 0.25 nM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Knight et al (2001)
A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces
ischemic myocardial injury in vitro and in vivo. J.Pharmacol.Exp.Ther. 297
254. Marala et al (2002) Zoniporide: a potent and highly
selective inhibitor of human Na+/H+ exchanger-1.
Eur.J.Pharmacol. 451 37. Clements-Jewery et al
(2004) Cardioprotective efficacy of zoniporide, a potent and selective
inhibitor of Na+/H+ exchanger isoform-1, in an experimental
model of cardiopulmonary bypass. Br.J.Pharmaocol. 142 57.
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View related products by Pharmacological Action
or by Research Area
Keywords: Zoniporide, Ion Pumps / Transporters, Selective NHE-1 Inhibitor, CP-597,396, Tocris Bioscience
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