Ziprasidone Hydrochloride | 5-HT Receptors | 5-HT2A / D2 Antagonist; Atypical Antipsychotic | CP 88059

Category:

7TM Receptors

5-HT Receptors

5-HT2 Receptors

5-HT2A

Cat.No.

Product Name

3085

Ziprasidone hydrochloride

Alternative name(s):

CP 88059

Ziprasidone hydrochloride C21H21ClN4OS.HCl 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride

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Ziprasidone hydrochloride

Chemical Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]- 6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride

Biological Activity:

Atypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT_2A receptors with a 5-HT_2A/D₂ affinity ratio greater than any other clinically available atypical antipsychotics (pK_i values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT_2A, 5-HT_2C, 5-HT_1D, 5-HT_1A, D₂, D₃, α₁, D₄, H₁ and D₁ receptors respectively).

Technical Data:

M.Wt:	449.4
Formula:	C₂₁H₂₁ClN₄OS.HCl
Storage:	Store at RT
Solubility:	Soluble to 10 mM in DMSO
Purity:	>99%
CAS No:	[138982-67-9]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Seeger et al (1995) Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J.Pharmacol.Exp.Ther. 275 101. Schmidt et al (2001) Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur.J.Pharmacol. 425 197. Fell et al (2005) Investigation into the effects of the novel antipsychotic ziprasidone on weight gain and reproductive function in female rats. Behav.Brain Res. 160 338.

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Keywords: Ziprasidone Hydrochloride, 5-HT Receptors, 5-HT2A / D2 Antagonist; Atypical Antipsychotic, CP 88059, Tocris Bioscience

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