Zaprinast | Phosphodiesterases | PDE5 / 6 / 9 / 11 Inhibitor

Category:

Cat.No.	Product Name
0947	Zaprinast

Price and Availability

Click here for full price details of
Zaprinast

Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one

Biological Activity:

Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC₅₀ values are 0.15, 0.76, 12.0 and 29.0 μM respectively).

Technical Data:

M.Wt:	271.28
Formula:	C₁₃H₁₃N₅O₂
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO
CAS No:	[37762-06-4]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Christensen and Torphy (1994) Isoenzyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Ann.Rep.Med.Chem. 29 185. Barbier and Lefebvre (1995) Relaxant influence of phosphodiesterase inhibitors in the cat gastric fundus. Eur.J.Pharmacol. 276 41. Soderling et al (1998) Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J.Biol.Chem. 273 15553. Lugnier (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol.Ther. 109 366.

View related products by Pharmacological Action or by Research Area

Keywords: Zaprinast, Phosphodiesterases, PDE5 / 6 / 9 / 11 Inhibitor, Tocris Bioscience

Literature in this Area

Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
View PDF

Unique & Diverse Compound Libraries

Tocriscreen Collections : For pricing and compound information click here

Fully annotated small molecule libraries for HTS, HCS and
chemical biology applications.

1120 compounds
Pre-dissolved in DMSO

Tocriscreen Total (250 μL/well)
Tocriscreen Mini (50 μL/well)

New Products in this Area

	3056	Pentoxifylline
	PDE inhibitor
	2845	IBMX
	PDE inhibitor (non-selective)

for new product e-alerts

User ID
Password