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Category:
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7TM Receptors Acetylcholine (Muscarinic) ReceptorsAntagonists
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Cat.No.
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Product Name
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2579 |
Zamifenacin fumarate
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| Alternative name(s): |
UK 76654 |
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Price and Availability
Click here for full price details of
Zamifenacin
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Chemical Name:
(3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmeth
oxy)piperidine fumarate |
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Biological Activity:
Selective M3 muscarinic receptor
antagonist (pKi values are 8.52, 7.93, 7.90 and 7.78 for M3,
M2, M1 and M4 receptors respectively).
Displays higher affinity at ileal M3 receptors (pKi =
9.3) compared to oesophageal and tracheal M3 receptors (pKi
values are 8.8 and 8.2 respectively). In vivo, inhibits gastrointestinal
motility in the absence of cardiovascular effects.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Wallis (1995)
Pre-clinical and clinical pharmacology of selective muscarinic M3
receptor antagonists. Life Sci. 56 861. Watson et al
(1995) Characterization of the interaction of zamifenacin at muscarinic
receptors in vitro. Eur.J.Pharmacol. 285 135. Choppin
(2002) Muscarinic receptors in isolated urinary bladder smooth muscle from
different mouse strains. Br.J.Pharmacol. 137 522.
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or by Research Area
Keywords: Zamifenacin, Acetylcholine (Muscarinic) Receptors, Selective M3 Antagonist, UK 76654, Tocris Bioscience
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| “Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..” Researcher, University of Aberdeen, UK |
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