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Category: EnzymesarrowKinasesarrowJak
Cat.No. Product Name
1367 ZM 39923 hydrochloride
Price and Availability

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ZM 39923 hydrochloride

Other Information:

Sold with the  permission of AstraZeneca Ltd
Chemical Name: 3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride

Biological Activity:

Potent, selective inhibitor of Janus tyrosine kinase 3 (Jak3). pIC50 values are 7.1, 5.6, 4.4, and < 5.0 for Jak3, EGFR, Jak1 and CDK4  respectively. Breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25ºC)  to form ZM 449829 (Cat. No. 1366).

Technical Data:

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M.Wt: 367.92
Formula: C23H25NO.HCl
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in DMSO
CAS No: [58753-54-1]

Resources:

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    • Certificate of Analysis / MSDS:

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    References:

    Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors. Bioorg.Med.Chem.Lett. 10 575.
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    Keywords: ZM 39923 Hydrochloride, Kinases, Potent, Selective Jak3 Inhibitor, ZM39923 Hydrochloride, Tocris Bioscience
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