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Category:
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Nuclear Receptors Estrogen and Related Receptors
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Cat.No.
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Product Name
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2183 |
ZK 164015
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Price and Availability
Click here for full price details of
ZK 164015
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Chemical Name:
2-(4-Hydroxyphenyl)-3-methyl-1-[10-(pentylsulfonyl)decy
l]-1H-indol-5-ol |
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Biological Activity:
Potent
estrogen receptor silent antagonist. Inhibits 17β-estradiol stimulation of luciferase
activity (IC50 = 0.025 μM) and potently inhibits the growth
of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC50
~ 1 nM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Biberger and von Angerer (1996)
2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity,
antiestrogenic potency, and antitumour activity. J.Steroid Biochem.Molec.Biol. 58
31. Liu et al (1999) The anti-estrogen hydroxytamoxifen is a
potent antagonist in a novel yeast system. Biol.Chem. 380 1341. Walter
et al (2004) Synthesis and biological evaluation of stilbene-based pure
estrogen antagonists. Bioorg.Med.Chem.Lett. 14 4659.
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View related products by Pharmacological Action
or by Research Area
Keywords: ZK 164015, Estrogen & Related Receptors, Potent Estrogen Receptor Antagonist, ZK164015, Tocris Bioscience
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Product Feature
Estrogen Receptors
Key estrogen receptors available from Tocris include:
2676
Y 134
Selective estrogen receptor modulator
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