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Category: EnzymesarrowKinasesarrowProtein Kinase C
Cat.No. Product Name
2549 ZIP
Alternative name(s): z-Pseudosubstrate inhibitory peptide
Price and Availability

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ZIP

Biological Activity:

Novel, cell-permeable inhibitor of protein kinase Mz (PKMz), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMz-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1-2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.  

Technical Data:

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M.Wt: 1928.4
Formula: C90H154N30O17
Storage: Desiccate at -20°C
CAS No: [863987-12-6]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295. Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979. Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141.
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    Keywords: ZIP, Kinases, Cell-permeable Inhibitor Of Atypical PKC Isozyme PKMz, Z-Pseudosubstrate Inhibitory Peptide, Tocris Bioscience
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