ZD 7288 | Other Channel Modulators | Sino-atrial Node Function Modulator (If Inhibitor) | ICI D7288 | ZD7288

Category:

Ion Channels

Other Channel Modulators

Cat.No.

Product Name

1000

ZD 7288

Alternative name(s):

ICI D7288

ZD 7288 C15H21ClN4 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride

Price and Availability

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ZD 7288

Other Information:

Sold with the permission of AstraZeneca UK Ltd

Chemical Name: 4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidini um chloride

Biological Activity:

Sino-atrial node function modulator; blocks the hyperpolarisation activated cation current I_f. Blocks I_h in central neurons. Increases NMDA-evoked noradrenaline release in rat brain in vitro.

Technical Data:

M.Wt:	292.81
Formula:	C₁₅H₂₁ClN₄
Storage:	Desiccate at +4°C
Solubility:	Soluble to 100 mM in Water
Purity:	>99%
CAS No:	[133059-99-1]

Resources:

Certificate of Analysis / MSDS:

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References:

BoSmith et al (1993) Inhibitory actions of ZENECA ZD7288 on whole cell hyperpolarization activated inward current (I_f) in guinea-pig dissociated sinoatrial node cells. Br.J.Pharmacol. 110 343. Harris and Constanti (1995) Mechanism of block by ZD7288 of the hyperpolarization-activated inward rectifying current in guinea-pig substantia nigra neurons in vitro. J.Neurophysiol. 74 2366. Green et al (1996) Pharmacological characterization of the inwardly rectifying current in the smooth muscle cells of the rat bladder. Br.J.Pharmacol. 119 1509. Klar et al (2003) I_h channels as modulators of presynaptic terminal function: ZD7288 increases NMDA-evoked [³H]-noradrenaline release in rat neocortex slices. Naunyn-Schmied.Arch.Pharmacol. 367 422.

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Keywords: ZD 7288, Other Channel Modulators, Sino-atrial Node Function Modulator (If Inhibitor), ICI D7288, ZD7288, Tocris Bioscience

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