YM 976 | Phosphodiesterases | PDE4 Inhibitor | YM976

Category:

Cat.No.	Product Name
1821	YM 976

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YM 976

Chemical Name: 4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2( 1H)-one

Biological Activity:

Orally active PDE4 inhibitor (IC₅₀ = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.

Technical Data:

M.Wt:	313.79
Formula:	C₁₇H₁₆ClN₃O
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Ethanol and to 100 mM in DMSO
Purity:	>98%
CAS No:	[191219-80-4]

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Certificate of Analysis / MSDS:

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References:

Aoki et al (2000) A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. J.Pharmacol.Exp.Ther. 295 255. Aoki et al (2001) Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. J.Pharmacol.Exp.Ther. 298 1142. Moriuchi et al (2003) Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur.J.Pharmacol. 470 57.

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Keywords: YM 976, Phosphodiesterases, PDE4 Inhibitor, YM976, Tocris Bioscience

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