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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA SelectivearrowAntagonists
Cat.No. Product Name
2701 YM 90K hydrochloride
Price and Availability

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YM 90K

Other Information:

Sold with the permission of Astellas Pharma Inc.
Chemical Name: 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalin edione hydrochloride

Biological Activity:

Selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischaemia model and cerebral infarction in a focal ischaemia model following postischaemic administration.

Technical Data:

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M.Wt: 309.67
Formula: C11H7N5O4.HCl
Storage: Desiccate at RT
Solubility: Soluble to 10 mM in DMSO
Purity: >99%
CAS No: [154164-30-4]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Ohmori et al (1994) 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor. J.Med.Chem. 37 467. Umemura et al (1997) Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia. Brain Res. 773 61. Nakano et al (2001) A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of N-acetylaspartate in the hippocampal CA1 area after transient unilateral forebrain ischemia in gerbils. Life Sci. 69 1983.
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    Keywords: YM 90K, Ligand-gated Ion Channels, Selective AMPA Antagonist, YM90K, Tocris Bioscience
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