TcY-NH2 | Peptides (Cardiovascular) | Selective PAR4 Antagonist | (trans-Cinnamoyl)-YPGKF-NH2 | TcYNH2

Category:

7TM Receptors

Peptides (Cardiovascular)

PAR Receptors

Cat.No.

Product Name

1488

tcY-NH₂

Alternative name(s):

(trans-Cinnamoyl)-YPGKF-NH₂

Price and Availability

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tcY-NH2

Biological Activity:

Selective PAR₄ antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.

Technical Data:

M.Wt:	739.87
Formula:	C₄₀H₄₉N₇O₇
Storage:	Desiccate at -20°C
CAS No:	[327177-34-4]

Resources:

Certificate of Analysis / MSDS:

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References:

Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439. Ma et al (2001) Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br.J.Pharmacol. 134 701. Hollenberg et al (2004) Proteinase-activated receptor-4:evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443.

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Keywords: TcY-NH2, Peptides (Cardiovascular), Selective PAR4 Antagonist, (trans-Cinnamoyl)-YPGKF-NH2, TcYNH2, Tocris Bioscience

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