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Category:
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Ion Channels Potassium ChannelsATP-Activated Potassium Channels
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Cat.No.
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Product Name
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2077 |
Y-27152
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Price and Availability
Click here for full price details of
Y-27152
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Chemical Name:
N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2
H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide |
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Biological Activity:
Prodrug
of the KATP channel opener Y-26763 (Cat. No. 2076). Inactive in
vitro; fails to modify tension in contracted aortic rings at concentrations up
to 1 μM. In vivo, produces long-lasting antihypertensive effects
with minimal tachycardia following oral administration in hypertensive animals.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Nakajima et al (1992) Y-27152, a long-acting K+ channel
opener with less tachycardia: antihypertensive effects in hypertensive rats and
dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. Fukunari
et al (1997) Y-26763 protects the canine heart from a stunning injury
through opening of the KATP channels. Eur.J.Pharmacol. 323
197.
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View related products by Pharmacological Action
or by Research Area
Keywords: Y-27152, Potassium Channels, Prodrug Of KATP Channel Opener Y-26763; Orally Active In Vivo, Y27152, Tocris Bioscience
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