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Category: Ion ChannelsarrowLigand-gated Ion Channelsarrow5-HT3 ReceptorsarrowAntagonists
Cat.No. Product Name
0380

Y-25130 hydrochloride  

Price and Availability

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Y-25130 hydrochloride

Other Information:

Not for sale in Japan
Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo -3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride

Biological Activity:

A selective and potent 5-HT3 antagonist (Ki = 2.9 nM).

Technical Data:

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M.Wt: 386.28
Formula: C17H20ClN3O3.HCl
Storage: Desiccate at -20°C
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [123040-16-4]

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    • Certificate of Analysis / MSDS:

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    References:

    Fukuda et al (1991) The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur.J.Pharmacol. 196 299. Sato et al (1992) Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 59 443. Haga et al (1993) The effects of orally administered Y-25130, a selective serotonin(3) receptor antagonist on chemotherapeutic agent-induced emesis. Jap.J.Pharmacol. 63 377.
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    Keywords: Y-25130 Hydrochloride, Ligand-gated Ion Channels, Potent, Selective 5-HT3 Antagonist, Y25130 Hydrochloride, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    5-HT Receptors & their Ligands
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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