WIN 55212-3 | Cannabinoid Receptors | CB2 Antagonist / CB1 Partial Inverse Agonist. Enantiomer Of Cat. No. 1038 | (S)-(-)-WIN 55,212 | WIN55212-3

Category:

7TM Receptors

Cannabinoid Receptors

Non-selective CB1/CB2

Cat.No.

Product Name

2327

WIN 55,212-3 mesylate

Alternative name(s):

(S)-(-)-WIN 55,212

WIN 55212-3 C27H26N2O3.CH3SO3H [(3S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone monomethanesulfonate

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WIN 55212-3

Chemical Name: [(3S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrro lo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methan one monomethanesulfonate

Biological Activity:

Novel, low potency CB₂ receptor silent antagonist and CB₁ receptor partial inverse agonist. Competitively antagonises effects of CP 55,940 (pA₂ = 6.1) and SR 144528 (pEC₅₀ = 5.3) at CB₂receptors and acts as a partial inverse agonist at CB₁receptors (pIC₅₀ = 5.5). Displays modest activity at human melatonin MT₁ and muscarinic M₄receptors, but is selective over several other GPCRs.

Technical Data:

M.Wt:	522.61
Formula:	C₂₇H₂₆N₂O₃.CH₃SO₃H
Storage:	Store at +4°C
Solubility:	Soluble to 100 mM in DMSO
Purity:	>98%
CAS No:	[131543-25-4]

Resources:

Certificate of Analysis / MSDS:

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References:

Savinainen et al (2005) Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB₂ receptor. Br.J.Pharmacol. 145 636.

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Keywords: WIN 55212-3, Cannabinoid Receptors, CB2 Antagonist / CB1 Partial Inverse Agonist. Enantiomer Of Cat. No. 1038, (S)-(-)-WIN 55,212, WIN55212-3, Tocris Bioscience

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