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Category:
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7TM Receptors PAF Receptors
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Cat.No.
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Product Name
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2339 |
WEB 2086
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| Alternative name(s): |
Apafant |
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Price and Availability
Click here for full price details of
WEB 2086
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Chemical Name:
4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,
4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine |
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Biological Activity:
Potent,
selective platelet-activating factor (PAF) receptor antagonist (Ki =
16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity.
Inhibits growth and proliferation of MCF-7 breast cancer cells.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Dent et al (1989) Characterization of PAF
receptors on human neutrophils using the specific antagonist, WEB 2086. FEBS
Lett. 244 365. Sariahmetoglu et al (1998) Effects
of WEB 2086 on the protective role of preconditioning against arrhythmias in
rats. Pharmacol.Res. 38 173. Cellai et al (2006)
Growth inhibition and differentiation of human breast cancer cells by the PAFR
antagonist WEB-2086. Br.J.Cancer 94 1637.
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View related products by Pharmacological Action
or by Research Area
Keywords: WEB 2086, PAF Receptors, Potent PAF Receptor Antagonist, Apafant, WEB2086, Tocris Bioscience
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Purity To Rely On
When choosing reagents for an experiment, the prime consideration is often to obtain the highest quality products available.
Unlike other suppliers, our in-house QC team carry out multiple analytical tests to thoroughly assess the purity of our reagents before they are offered for sale.
This accurate purity data is available on a batch-specific basis for every product via our website. At Tocris we work hard to ensure that we always supply to the highest possible standards of purity.
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