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Category:
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Transporters Neurotransmitter TransportersGlutamate Transporters
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Cat.No.
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Product Name
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2652 |
WAY 213613
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Price and Availability
Click here for full price details of
WAY 213613
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Chemical Name:
N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine |
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Biological Activity:
Potent, nonsubstrate inhibitor of EAAT2 (GLT-1)
that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50
values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively).
Exhibits no activity towards ionotropic and metabotropic glutamate receptors.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Dunlop et al
(2005) Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid
and diaminopropionic acid analogs as potent inhibitors of the high-affinity
glutamate transporter EAAT2. Mol.Pharmacol. 68 974. Beart and
Shea (2007) Transporters for L-glutamate:
an update on their molecular pharmacology and pathological involvement.
Br.J.Pharmacol. 150 5.
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or by Research Area
Keywords: WAY 213613, Neurotransmitter Transporters, Potent, Nonsubstrate EAAT2 Inhibitor, WAY213613, Tocris Bioscience
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Product Feature
Uptake Inhibitors
Key Uptake Inhibitors now available from Tocris include:
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