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Category:
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Enzymes DeacetylasesHistone Deacetylase
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Cat.No.
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Product Name
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2815 |
Valproic acid, sodium salt
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| Alternative name(s): |
Sodium
Valproate |
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Price and Availability
Click here for full price details of
Valproic acid, sodium salt
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Chemical Name:
Sodium 2-propylpentanoate |
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Biological Activity:
Histone deacetylase inhibitor (IC50 =
400 μM)
that exhibits anticancer, anti-inflammatory and neuroprotective effects.
Displays anticonvulsive activity via an increase in GABA levels. Also
attenuates NMDA-mediated excitation, blocks voltage-gated Na+
channels and modulates firing of neurons.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Phiel et al (2001)
Histone deacetylase is a direct target of valproic acid, a potent
anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 276
36734. Kostrouchova et al (2007) Valproic acid, a molecular lead
to multiple regulatory pathways. Folia Biologica 53 37. Kim et
al (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and
neuroprotective effects in a rat permanent ischemic model of stroke: multiple
mechanisms of action. J.Pharmacol.Exp.Ther. 321 892.
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Keywords: Valproic Acid, Sodium Salt, Deacetylases, Histone Deacetylase Inhibitor, Sodium Valproate, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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