Tocris Bioscience
Welcome to Tocris

| Advanced Search
Home Products Technical Support Customer Support Literature Custom Synthesis
Category: EnzymesarrowProteasesarrowCaspase
Cat.No. Product Name
2169 Z-VEID-FMK
Price and Availability

Click here for full price details of
Z-VEID-FMK
Chemical Name: Benzyloxycarbonyl-Val-Glu(OMe)-Ile-Asp(OMe)-fluoromethy lketone

Biological Activity:

Irreversible caspase-6 inhibitor. Inhibits nuclear protein cleavage in Fas antibody-treated HeLa cells.

Technical Data:

Click here for more information on batch specific data
M.Wt: 652.72
Formula: C31H45FN4O10
Storage: Store at -20°C
Solubility: Soluble to 20 mM in DMSO

Resources:

  • Certificate of Analysis / MSDS:

    Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
    No Product/Material Safety Data Sheet available.
    Please contact Customer Service

    References:

    Abdo et al (2003) Role of tumor necrosis factor-alpha and the modulating effect of the caspases in rat corpus luteum apoptosis. Biol.Reprod. 68 1241. Nyormoi et al (2003) Sequence-based discovery of a synthetic peptide inhibitor of caspase 6. Apoptosis 8 371. Taimen and Kallajoki (2003) NuMA and nuclear lamins behave differently in Fas-mediated apoptosis. J.Cell Sci. 116 571.
    View related products by Pharmacological Action or by Research Area

    Keywords: Z-VEID-FMK, Proteases, Irreversible Caspase-6 Inhibitor, ZVEID-FMK, Tocris Bioscience

    Literature in this Area
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    Product Feature
    Proteasome and NF-κB
    Key proteasome inhibitors now available from Tocris include:
    2564   AM 114
    20S proteasome inhibitor
    1748   MG 132
    Proteasome & calpain inhibitor. Inhibits NF-κB activation
    2267   Lactacystin
    Cell-permeable, potent & selective proteasome inhibitor
    2637   Gliotoxin
    Immunosuppressant; inhibits NF-κB & cytokine production
    View Product Feature
    New Products in this Area

     2790K 579
     Dipeptidyl peptidase IV (DPP-IV) inhibitor
     2520PD 166793
     Broad spectrum matrix metalloproteinase (MMP) inhibitor
     2628ONO 4817
     Broad spectrum MMP inhibitor
     2783DPPI 1c hydrochloride
     Dipeptidyl peptidase IV (DPP-IV) inhibitor
     2636Ivachtin
     Potent caspase-3 inhibitor
     2631Marimastat
     Broad spectrum MMP inhibitor
     2633WAY 170523
     Potent and selective inhibitor of MMP-13
     2709Cilastatin sodium
     Dipeptidase inhibitor
     2632CL 82198 hydrochloride
     Selective inhibitor of MMP-13
     2691Moexipril hydrochloride
     Angiotensin-converting enzyme (ACE) inhibitor
     2677JLK 6
     Inhibitor of γ-secretase-mediated βAPP processing
     2675ZJ 43
     Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor
     2647NSC 632839 hydrochloride
     Inhibitor of ubiquitin isopeptidase activity
     2622ARP 101
     Inhibitor of MMP-2
     2634DAPT
     γ-secretase inhibitor
     2512CGS 35066
     Endothelin-converting enzyme (ECE) inhibitor
     2621ARP 100
     Selective inhibitor of MMP-2
     2654Compound W
     γ-secretase inhibitor
     2564AM 114
     20S proteasome inhibitor
     1380PMPA (NAALADase inhibitor)
     GCP II inhibitor
     2581PAC 1
     Activator of procaspase-3; proapoptotic
     2578Benazepril hydrochloride
     Angiotensin-converting enzyme (ACE) inhibitor
     2506SSR 69071
     Potent, orally active human leukocyte elastase inhibitor
    Sign-up for new product e-alerts
    Log In / Register

    User ID
    Password
    If you are not registered with us Create Account