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Category:
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Enzymes ProteasesCaspase
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Cat.No.
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Product Name
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2165 |
Z-VDVAD-FMK
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Price and Availability
Click here for full price details of
Z-VDVAD-FMK
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Chemical Name:
Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluorom
ethylketone |
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Biological Activity:
Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced
cleavage of PARP and apoptosis in endothelial cells.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Gamen et al (2000) Doxorubicin treatment activates a
Z-VAD-sensitive caspase, which causes Dyμ loss, caspase-9
activity, and apoptosis in Jurkat cells. Exp.Cell Res. 258 223. Meguro
et al (2001) Caspase inhibitors attenuate oxyhemoglobin-induced
apoptosis in endothelial cells. Stroke 32 561. Robertson et
al (2002) Caspase-2 acts upstream of mitochondria to promote cytochrome c
release during etoposide-induced apoptosis. J.Biol.Chem. 277
29803.
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View related products by Pharmacological Action
or by Research Area
Keywords: Z-VDVAD-FMK, Proteases, Irreversible Caspase-2 Inhibitor, ZVDVAD-FMK, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
Proteasome and NF-κB
Key proteasome inhibitors now available from Tocris include:
1748
MG 132
Proteasome & calpain inhibitor. Inhibits NF-κB activation
2637
Gliotoxin
Immunosuppressant; inhibits NF-κB & cytokine production
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