Z-VAD-FMK | Proteases | Cell-permeable, Irreversible Caspase Inhibitor | ZVAD-FMK

Category:

Cat.No.	Product Name
2163	Z-VAD-FMK

Price and Availability

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Z-VAD-FMK

Chemical Name: Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone

Biological Activity:

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumour cells in vitro (IC₅₀ = 0.0015-5.8 μM). Active in vivo.

Technical Data:

M.Wt:	467.49
Formula:	C₂₂H₃₀FN₃O₇
Storage:	Store at -20°C
Solubility:	Soluble to 20 mM in DMSO

Resources:

Certificate of Analysis / MSDS:

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References:

Slee et al (1996) Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem.J. 315 21. Kunstle et al (1997) ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α. Immunol.Lett. 55 5. Garcia-Calvo et al (1998) Inhibition of human caspases by peptide-based and macromolecular inhibitors. J.Biol.Chem. 273 32608. King et al (1998) Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lyphocytic leukemia cells. Leukemia 12 1553.

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Keywords: Z-VAD-FMK, Proteases, Cell-permeable, Irreversible Caspase Inhibitor, ZVAD-FMK, Tocris Bioscience

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