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Urotensin II (human)
Biological Activity:
Potent
endogenous peptide agonist for the urotensin II receptor (EC50 = 0.1
nM). Displays arterio-selective vasoconstriction and vasodilatation in mammals
in vitro and in vivo, effects which vary between species. Also has been shown
to mediate bronchoconstriction.
Coulouarnet al (1998) Cloning of the
cDNA encoding the urotensin II precursor in frog and human reveals intense
expression of the urotensin II gene in motoneurones of the spinal cord.
Proc.Natl.Acad.Sci.USA 95 15803. Nothackeret al (1999)
Identification of the natural ligand of an orphan G-protein-coupled receptor
involved in the regulation of vasoconstriction. Nature Cell Biol. 1
383. Maguire and Davenport (2002) Is urotensin-II the new endothelin?
Br.J.Pharmacol. 137 579.
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