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Category: 7TM ReceptorsarrowOpioid ReceptorsarrowKappa ReceptorsarrowAgonists
Cat.No. Product Name
0496 (-)-U-50488 hydrochloride  
Price and Availability

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(-)-U-50488 hydrochloride
Chemical Name: trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cy clohexyl]benzeneacetamide hydrochloride

Biological Activity:

More active enantiomer of (±)-U-50488 (Cat. No. 0495).

Technical Data:

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M.Wt: 405.79
Formula: C19H26Cl2N2O.HCl
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [67198-19-0]

Resources:

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    References:

    De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a k-opioid receptor selective antagonist. FEBS Lett. 223 335. Morrone et al (1993) Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa opioid receptors. Br.J.Pharmacol. 109 48. Reddy and Bhargava (1993) Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central dopamine (D2) receptors of the rat. Eur.J.Pharmacol. 235 23. Zhu et al (1998) Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 285 28.
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    Keywords: (-)-U-50488 Hydrochloride, Opioid Receptors, More Active Enantiomer Of Cat. No. 0495, U50488 Hydrochloride, Tocris Bioscience

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