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Category:
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Cellular Processes and Components Cytoskeleton and Motor ProteinsKinesin
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Cat.No.
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Product Name
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2191 |
S-Trityl-L-cysteine
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| Alternative name(s): |
NSC 83265 |
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Price and Availability
Click here for full price details of
S-Trityl-L-cysteine
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Chemical Name:
S-(Triphenylmethyl)-L-cysteine |
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Biological Activity:
Potent,
cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required
for establishing and maintaining a bipolar spindle. Inhibits basal ATPase
activity (IC50 = 1 μM) and microtubule-activated ATPase
activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa
cells with an IC50 of 700 nM. Displays anti-tumour activity.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
DeBonis et al
(2004) In vitro screening for inhibitors of the human mitotic kinesin
Eg5 with antimitotic and antitumour activities. Mol.Cancer Ther. 3
1079. Brier et al (2004) Identification of the protein binding
region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5.
Biochemistry 43 13072.
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View related products by Pharmacological Action
or by Research Area
Keywords: S-Trityl-L-cysteine, Cytoskeleton & Motor Proteins, Potent, Selective Inhibitor Of Mitotic Kinesin Eg5, NSC 83265, STrityl-L-cysteine, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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