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Category:
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Enzymes Phosphodiesterases
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Cat.No.
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Product Name
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2337 |
Trequinsin hydrochloride
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| Alternative name(s): |
HL-725 |
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Price and Availability
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Trequinsin
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Chemical Name:
2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-tr
imethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-on
e hydrochloride |
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Biological Activity:
Extremely
potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC50 =
250 pM). Potently inhibits arachidonic acid-induced aggregation of human
platelets (IC50 = 50 pM). Orally active antihypertensive agent;
reduces systemic blood pressure in both normotensive and hypertensive animal
models.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Ruppert
and Weithmann (1982)
HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced
platelet aggregation in vitro. Life Sci. 31 2037. Lal et
al (1984) Trequinsin, a potent new antihypertensive vasodilator in the
series of 2-(arylimino)-3-alkyl-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-ones.
J.Med.Chem. 27 1470. Agarwal et al (1987) Role of
plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of
cAMP phosphodiesterase: species differences. Thromb.Res. 47 191.
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or by Research Area
Keywords: Trequinsin, Phosphodiesterases, Ultrapotent Inhibitor Of PDE3, HL-725, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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