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Category:
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Enzymes Oxygenases/OxidasesCyclooxygenase
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Cat.No.
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Product Name
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2580 |
Tenidap
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| Alternative name(s): |
CP 66248 |
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Price and Availability
Click here for full price details of
Tenidap
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Chemical Name:
5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-o
xo-1H-indole-1-carboxamide |
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Biological Activity:
NSAID that preferentially inhibits COX-1 (IC50
values are < 0.03, 1.2 and > 30 μM for COX-1,
COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory
arachidonic acid metabolites in isolated human peripheral polymorphonuclear
leukocytes. Opener of inward rectifying hKIR2.3 channel (EC50
= 402 nM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Moilanen et al
(1988) CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of
leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes
in vitro. Eicosanoids 1 35. Kirchner et al (1997)
Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2
selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of
inflammation. J.Pharmacol.Exp.Ther. 282 1094. Liu et al
(2002) Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly
rectifying K+ channel hKir2.3. Eur.J.Pharmacol. 435
153.
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View related products by Pharmacological Action
or by Research Area
Keywords: Tenidap, Oxygenases / Oxidases, NSAID, Cyclooxygenase (COX-1) Inhibitor. Also Opener Of KIR2.3, CP 66248, Tocris Bioscience
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