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Category:
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Cellular Processes and Components ApoptosisApoptosis Inducer
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Cat.No.
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Product Name
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2706 |
Temozolomide
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| Alternative name(s): |
NSC 362856 |
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CCRG 81045 |
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Price and Availability
Click here for full price details of
Temozolomide
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Chemical Name:
3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetraz
ine-8-carboxamide |
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Biological Activity:
DNA methylating, chemotherapeutic agent.
Displays antitumour activity against a board spectrum of tumours, including
leukaemias, lymphomas and solid tumours (IC50 = 5.0 μM for
cytotoxicity against mouse TLX5 lymphoma cells).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Plowman et al
(1994) Preclinical antitumor activity of temozolomide in mice: efficacy against
human brain tumor xenografts and synergism with
1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 54 3793. Clark
et al (1995) Antitumor imidazotetraazines. 32. Synthesis of novel
imidazotetrazinones and related bicyclic heterocycles to probe the mode of
action of the antitumor drug temozolomide. J.Med.Chem. 38 1493. Bodell
et al (2003) Formation of DNA adducts and induction of lacI
mutations in big blue rat-2 cells treated with temozolomide: implications for
the treatment of low-grade adult and pediatric tumors. Cancer
Epidemiol.Biomarkers Prevent. 12 545.
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Keywords: Temozolomide, Apoptosis, DNA-methylating Antitumour Agent, NSC 362856, CCRG 81045, Tocris Bioscience
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Literature in this Area Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
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