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Category:
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Enzymes PhosphatasesPP
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Cat.No.
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Product Name
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2305 |
Tautomycetin
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Price and Availability
Click here for full price details of
Tautomycetin
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Chemical Name:
(1R,2S,3R,6S,7S,10S,12R,15E,bR,3R)-16-Ethyl-3,7-dihydro
xy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadie
nyl
2,5-dihydro-b-hydroxy-4-methyl-2,5-dioxo-3-furanpropano
ic acid ester |
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Biological Activity:
Potent
activated T cell-specific immunosuppressor. Selectively inhibits PP1 over PP2
with IC50 values of 1.6 and 62 nM respectively. Active in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Cheng et al
(1989) A new antibiotic, tautomycetin. J.Antibiot. 42 141. Mitsuhashi
et al (2001) Tautomycetin is a novel and specific inhibitor of
serine/threonine protein phosphatase type 1, PP1. Biochem.Biophys.Res.Comm. 287
328. Shim et al (2002) Immunosuppressive effects of tautomycetin in
vivo and in vitro via T cell-specific apoptosis induction.
Proc.Natl.Acad.Sci.USA. 99 10617.
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or by Research Area
Keywords: Tautomycetin, Phosphatases, Selective PP1 Inhibitor, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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