Tamoxifen Citrate | Estrogen & Related Receptors | Estrogen Receptor Partial Agonist / Antagonist

Category:

Cat.No.	Product Name
0999	Tamoxifen citrate

Price and Availability

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Tamoxifen citrate

Other Information:

Sold with the permission of AstraZeneca UK Ltd

Chemical Name: (2)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethyle thanamine citrate

Biological Activity:

Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo. Also high affinity ligand at the membrane estrogen receptor GPR30.

Technical Data:

M.Wt:	563.65
Formula:	C₂₆H₂₉NO.C₆H₈O₇
Storage:	Desiccate at RT
Solubility:	Soluble to 15 mM in Ethanol and to 100 mM in DMSO
Purity:	>99%
CAS No:	[54965-24-1]

Resources:

Certificate of Analysis / MSDS:

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Product/Material Safety Data Sheet: View current batch

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References:

Merck Index 12 9216. Wakeling et al (1984) Non steroidal anti-estrogens - receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells. J.Steroid Biochem. 20 111. Paul et al (1998) Both the immunosuppressant SR31747 and the antioestrogen tamoxifen bind to an emopamil-insensitive site of mammalian D8-D7 sterol isomerase. J.Pharmacol.Exp.Ther. 285 1302. Mehta et al (2003) Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat. Neuroendocrinology. 77 44. Thomas et al (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinol. 146 624.

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Keywords: Tamoxifen Citrate, Estrogen & Related Receptors, Estrogen Receptor Partial Agonist / Antagonist, Tocris Bioscience

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Product Feature

Estrogen Receptors

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2183 ZK 164015

Potent estrogen receptor silent antagonist

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