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Category:
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7TM Receptors Peptides (Hypothalamic/Pituitary Hormones)Thyrotropin-releasing Hormone Receptors
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Cat.No.
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Product Name
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2672 |
Taltirelin
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| Alternative name(s): |
TA 0910 |
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Price and Availability
Click here for full price details of
Taltirelin
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Chemical Name:
N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]ca
rbonyl]-L-histidyl-L-prolinamide |
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Biological Activity:
Synthetic thyrotropin-releasing hormone (TRH)
analogue. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker
endocrine activity than TRH. Antinociceptive and neuroprotective.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Suzuki et al
(1990) Synthesis and central nervous system actions of thyrotropin-releasing
hormone analogues containing a dihydroorotic acid moiety. J.Med.Chem. 33
2130. Urayama et al (2002) Neuroprotective effect and brain
receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH)
analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sci. 72
601. Tanabe et al (2007) The synthetic TRH analogue taltirelin
exerts modality-specific antinociceptive effects via distinct descending
monoaminergic systems. Br.J.Pharmacol. 150 403.
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or by Research Area
Keywords: Taltirelin, Peptides (Hypothalamic / Pituitary Hormones), Synthetic Thyrotropin-releasing Hormone (TRH) Analogue, TA 0910, Tocris Bioscience
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Literature in this Area Endocrinology Product Guide | A collection of more than 250 products related to endocrinology research, including the very latest exclusive research tools. | | Request Copy / View PDF |
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