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Category:
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Ion Channels Chloride Channels
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Cat.No.
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Product Name
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2510 |
Talniflumate
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Price and Availability
Click here for full price details of
Talniflumate
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Chemical Name:
2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-
1-isobenzofuranyl 3-pyridinecarboxylic acid ester |
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Biological Activity:
Calcium-activated
chloride channel (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release
in cell culture and animal models. Possesses anti-inflammatory actions via
inhibition of cyclooxygenases and inhibits Cl-/HCO3-
exchanger activity. Increases survival in a cystic fibrosis mouse model of
distal intestinal obstructive syndrome.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Sanchez
et al (1982) Action of a non-steroidal
anti-inflammatory drug on gastric mucosa of rats. J.Appl.Toxicol. 2
42. Knight (2004) Talniflumate (Genaera). Curr.Opin.Invest.Drugs 5
557. Walker et al (2006) Talniflumate increases survival in a
cystic fibrosis mouse model of distal intestinal obstructuve syndrome.
J.Pharmacol.Exp.Ther. 317 275.
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Keywords: Talniflumate, Chloride Channels, Chloride Channel Blocker (hCLCA1 / MCLCA3 & Cl- / HCO3- Exchange), Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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