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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowAcetylcholine (Nicotinic) ReceptorsarrowOther Acetylcholine
Cat.No. Product Name
0965 Tacrine hydrochloride
Price and Availability

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Tacrine hydrochloride
Chemical Name: 1,2,3,4-Tetrahydro-5-aminoacridine hydrochloride

Biological Activity:

Potent cholinesterase inhibitor, a cognition enhancer in vivo.

Technical Data:

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M.Wt: 234.73
Formula: C13H14N2.HCl
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [1684-40-8]

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    References:

    Merck Index 12 9199. Summers and Kaufman (1980) THA- A review of the literature and its use in treatment of five overdose patients. Clin.Toxicol. 16 269. Freeman and Dawson (1991) Tacrine: a pharmacological review. Progr.Neurobiol. 36 257. Osborne and Christie (1996) Tetrahydro-9-aminoacridine has mixed actions on muscarinic currents and blocks opioid currents in rat locus ceruleus neurons. J.Pharmacol.Exp.Ther. 276 137. Snape et al (1999) A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology 38 181.

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    Keywords: Tacrine Hydrochloride, Ligand-gated Ion Channels, Cholinesterase Inhibitor, Tocris Bioscience
    Literature in this Area
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    Nicotinic ACh Receptors
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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    Product Feature
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