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Category:
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7TM Receptors Peptides (Gastrointestinal)Ghrelin Receptors
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Cat.No.
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Product Name
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2308 |
Tabimorelin hemifumarate
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| Alternative name(s): |
NN 703 |
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Price and Availability
Click here for full price details of
Tabimorelin
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Chemical Name:
N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2
-naphthalenyl)-D-alanyl-N,Na-dimethyl-D-phenylalaninami
de hemifumarate |
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Biological Activity:
Potent,
orally active growth hormone secretagogue (GHS) receptor agonist (Ki
= 50 nM at human recombinant GHS-R 1A). Stimulates GH release from rat
pituitary cells with an EC50 value of 2.7 nM. Induces hyperphagia
and adiposity in lean rats, but not in leptin signalling-deficient ZDF rats.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Hansen et al (1999) Pharmacological
characterisation of a new oral GH secretagogue, NN703. Eur.J.Endocrinol. 141
180. Holm et al (2004) Adipogenic and orexigenic effects of the
ghrelin-receptor ligand tabimorelin are diminished in
leptin-signalling-deficient ZDF rats. Eur.J.Pharmacol. 150 893.
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View related products by Pharmacological Action
or by Research Area
Keywords: Tabimorelin, Peptides (Gastrointestinal), Potent, Orally Active GHS Receptor Agonist, NN 703, Tocris Bioscience
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| “I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..” Researcher, University of Pisa, Italy |
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