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Category:
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Nuclear Receptors LXR-like Receptors
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Cat.No.
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Product Name
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2373 |
T 0901317
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Price and Availability
Click here for full price details of
T 0901317
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Chemical Name:
N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydrox
y-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide |
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Biological Activity:
Potent,
high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd
values are 7 and 22 nM for LXR-α and LRXR-β respectively). Upregulates
expression of the ABCA1 gene associated with cholesterol efflux regulation and
HDL metabolism. Decreases amyloid-β production in primary neurons in
vitro. Displays an EC50 of ~ 5 μM for activation of bile acid
farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand
chenodeoxycholic acid.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Repa et al (2000)
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR
heterodimers. Science 289 1524. Houck et al (2004)
T0901317 is a dual LXR/FXR agonist. Mol.Gen.Metab. 83 184. Koldamova
et al (2005) The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a
mouse model of Alzheimer's disease. J.Biol.Chem. 280 4079. Mitro
et al (2007) The nuclear receptor LXR is a glucose sensor. Nature Lett. 445
219.
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Keywords: T 0901317, LXR-like Receptors, Potent Liver X Receptor (LXR) Agonist, T0901317, Tocris Bioscience
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