TRIM | Synthases / Synthetases | NNOS / INOS Inhibitor

Category:

Cat.No.	Product Name
0919	TRIM

Price and Availability

Click here for full price details of
TRIM

Chemical Name: 1-(2-Trifluoromethylphenyl)imidazole

Biological Activity:

A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC₅₀ values of 28.2, 27.0 and 1057.5 μM respectively). Antinociceptive in vivo.

Technical Data:

M.Wt:	212.17
Formula:	C₁₀H₇F₃N₂
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Ethanol and to 50 mM in DMSO
CAS No:	[25371-96-4]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

For specific/earlier batch please select:

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Handy et al (1995) The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br.J.Pharmacol. 116 2349. Handy et al (1996) Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl)imidazole (TRIM) in vivo: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 119 423.

View related products by Pharmacological Action or by Research Area

Keywords: TRIM, Synthases / Synthetases, NNOS / INOS Inhibitor, Tocris Bioscience

Literature in this Area

Signal Transduction Guide

	A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
View PDF

“I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..”

Researcher, University of Pisa, Italy

New Products in this Area

Check back soon!
We are currently working on new products for this area

User ID
Password