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Category:
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Transporters Neurotransmitter TransportersGlutamate Transporters
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Cat.No.
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Product Name
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2532 |
TFB-TBOA
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Price and Availability
Click here for full price details of
TFB-TBOA
Other Information:
Sold for
research purposes under licence from Suntory Ltd
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Chemical Name:
(3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]me
thoxy]-L-aspartic acid
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Biological Activity:
High affinity, selective blocker of glial
glutamate transporters EAAT1 and EAAT2 (IC50 values are 17, 22 and
300 nM for EAAT2, EAAT1 and EAAT3 respectively). Displays no activity on a wide
range of neurotransmitter receptors and transporters. Induces convulsions
following i.c.v. administration in mice.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Shimamoto et al
(2004) Characterization of novel L-threo-β-benzyloxyaspartate derivative,
potent blockers of the glutamate transporters. Mol.Pharmacol. 65
1008. Tsukada et al (2005) Effects of a novel glutamate
transporter blocker, (2S, 3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate
(TFB-TBOA), on activities of hippocampal neurons. Neuropharmacol. 48
479. Shimamoto and Shigeri (2006) Elucidation of glutamate transporter
functions using selective inhibitors. CNS Agents Med.Chem. 6 59.
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View related products by Pharmacological Action
or by Research Area
Keywords: TFB-TBOA, Neurotransmitter Transporters, High Affinity EAAT1 & EAAT2 Blocker, TFBTBOA, Tocris Bioscience
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Product Feature
Uptake Inhibitors
Key Uptake Inhibitors now available from Tocris include:
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