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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowGABAA ReceptorsarrowAgonists
Cat.No. Product Name
2905 TB 21007
Price and Availability

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TB 21007
Chemical Name: 6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2- thiazolyl)-benzo[c]thiophen-4(5H)-one

Biological Activity:

GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.

Technical Data:

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M.Wt: 339.5
Formula: C15H17NO2S3
Storage: Store at +4°C
Solubility: Soluble to 100 mM in DMSO and to 25 mM in Ethanol
Purity: >99%
CAS No: [207306-50-1]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Chambers et al (2003) Identification of a novel, selective GABA5 α5 receptor inverse agonist which enhances cognition. J.Med.Chem. 46 2227.
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    Keywords: TB 21007, Ligand-gated Ion Channels, A5-selective GABAA Inverse Agonist, TB21007, Tocris Bioscience
    Literature in this Area
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    GABA Receptors
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