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Category:
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Nuclear Receptors PPAR Receptors
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Cat.No.
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Product Name
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2301 |
T 0070907
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Price and Availability
Click here for full price details of
T0070907
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Chemical Name:
2-Chloro-5-nitro-N-4-pyridinylbenzamide |
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Biological Activity:
Potent and selective PPARγ antagonist
(IC50 = 1 nM). Displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. In vitro,
blocks transcriptional activity of PPARγ and inhibits
rosiglitazone-induced adipogenesis.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Lee et al (2002) T0070907,
a selective ligand for peroxisome proliferator-activated receptorγ, functions as an antagonist of
biochemical and cellular activities. J.Biol.Chem. 277 19649. Rockwell
and Kaminski (2004) A cyclooxygenase metabolite of anandamide causes
inhibition of interleukin-2 secretion in murine splenocytes.
J.Pharmacol.Exp.Ther. 311 683. Schaefer et al
(2005) Peroxisome proliferator-activated receptor gamma inhibition prevents
adhesion to the extracellular matrix and induces anoikis in hepatocellular
carcinoma cells. Cancer Res. 65 2251.
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Keywords: T0070907, PPAR Receptors, Highly Potent & Selective PPARg Antagonist, Tocris Bioscience
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