Spiperone | 5-HT Receptors | 5-HT2A Antagonist. Also D2-like Antagonist

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Cat.No.	Product Name
0995	Spiperone hydrochloride

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Spiperone

Chemical Name: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triaza spiro[4,5]decan-4-one hydrochloride

Biological Activity:

5-HT_2A serotonin and selective D₂-like dopamine receptor antagonist (K_i values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D₂, D₃, D₄, D₁ and D₅ receptors respectively). Antipsychotic.

Technical Data:

M.Wt:	431.94
Formula:	C₂₃H₂₆FN₃O₂.HCl
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO
Purity:	>98%
CAS No:	[749-02-0]

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Certificate of Analysis / MSDS:

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References:

Merck Index 12 8903. Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157. Seeman and van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264.

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Keywords: Spiperone, 5-HT Receptors, 5-HT2A Antagonist. Also D2-like Antagonist, Tocris Bioscience

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Scientific Reviews

5-HT Receptors & their Ligands
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