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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowPolyamine SitearrowAgonists
Cat.No. Product Name
0959 Spermidine trihydrochloride  
Price and Availability

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Spermidine trihydrochloride
Chemical Name: N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride

Biological Activity:

Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [3H]-MK801.

Technical Data:

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M.Wt: 254.63
Formula: C7H19N3.3HCl
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in Water
CAS No: [334-50-9]

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    References:

    Williams et al (1989) Effects of polyamines on the binding of [3H]-MK801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site? Mol.Pharmacol. 36 375. Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163. Kishi et al (1998) Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats. Brain Res. 793 311.

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    Keywords: Spermidine Trihydrochloride, Ligand-gated Ion Channels, Agonist At Polyamine Site, Tocris Bioscience
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