This is a controlled substance in some countries with
associated conditions of supply; the relevant licence/documentation from the
appropriate governing body may be required.
Chemical Name:1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclo
butanemethanamine hydrochloride
Biological Activity:
5-HT
and noradrenaline re-uptake inhibitor (SNRI). Produces weight loss in rats via
inhibition of food intake and increased energy expenditure. Antidepressant.
Buckettet al (1988) The pharmacology of sibutramine hydrochloride
(BTS 54524), a new antidepressant which induces rapid noradrenergic
down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575. Jacksonet al (1997) Comparison of the effects of sibutramine and other
monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121
1758. Gundlahet al (1997) In vivo criteria to
differentiate monoamine reuptake inhibitors from releasing agents: sibutramine
is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581.
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