Salvinorin A | Opioid Receptors | Highly Potent & Selective K-opioid Agonist | Divinorin A

Category:

7TM Receptors

Opioid Receptors

Kappa Receptors

Agonists

Cat.No.

Product Name

2134

Salvinorin A

Alternative name(s):

Divinorin A

Salvinorin A C23H28O8 (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

Price and Availability

Click here for full price details of
Salvinorin A

Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl )dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1- c]pyran-7-carboxylic acid methyl ester

Biological Activity:

Potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (K_i = 4.3 nM) and cloned (K_i = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties.

Technical Data:

M.Wt:	432.47
Formula:	C₂₃H₂₈O₈
Storage:	Desiccate at -20°C
Solubility:	Soluble to 10 mM in Ethanol
CAS No:	[83729-01-5]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

For specific/earlier batch please select:

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Roth et al (2002) Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist. Proc.Natl.Acad.Sci.USA 99 11934. Scheffler and Roth (2003) Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor. TiPS. 24 107. Rothman et al (2007) Salvinorin A: allosteric interactions at the μ-opioid receptor. J.Pharmacol.Exp.Ther. 320 801.

View related products by Pharmacological Action or by Research Area

Keywords: Salvinorin A, Opioid Receptors, Highly Potent & Selective K-opioid Agonist, Divinorin A, Tocris Bioscience

Literature in this Area

Scientific Reviews

Opioid Receptors
Download PDF

Featured New Product

Selective NOP Antagonist

2598 (±)-J 113397

Potent and selective nociceptin / orphanin FQ (NOP, ORL₁) receptor antagonist (IC₅₀ values are 2.3,1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively). Inhibits nociceptin / orphanin FQ-induced hyperalgesia in the mouse tail-flick test.

View all Featured New Products

New Products in this Area

	2965	Diprenorphine
	Non-selective opioid antagonist
	2598	(±)-J 113397
	Potent and selective NOP antagonist
	2601	Cyprodime hydrochloride
	Selective μ antagonist
	2508	Trap 101
	Potent and selective NOP antagonist

for new product e-alerts

User ID
Password