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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA / Kainate SelectivearrowAntagonists
Cat.No. Product Name
0961 SYM 2206  
Price and Availability

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SYM 2206

Other Information:

Sold with the permission of Annovis Inc
Chemical Name: (±)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarb amoyl-6,7-methylenedioxyphthalazine

Biological Activity:

Novel, potent, non-competitive AMPA receptor antagonist (IC50 = 2.8 μM ). Acts allosterically at the same regulatory site as GYKI 52466 and 53655 and other benzodiazepines but does not bind to the central diazepine binding site. Selective for AMPA relative to kainate receptor sub-types. Similar potency to GYKI 53655. Anticonvulsant in vivo.

Technical Data:

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M.Wt: 366.42
Formula: C20H22N4O3
Storage: Store at RT
Solubility: Soluble to 100 mM in Ethanol and to 100 mM in DMSO
CAS No: [173952-44-8]

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    References:

    Li et al (1996) Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord. Nature 397 161. Pelletier et al (1996) Substituted 1,2-dihydrophthalazines: potent, selective and non-competitive inhibitors of the AMPA receptor. J.Med.Chem. 39 343. Bleakman et al (2002) Kainate receptor agonists, antagonists and allosteric modulators. Curr.Pharm.Des. 8 873.
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    Keywords: SYM 2206, Ligand-gated Ion Channels, Non-competitive AMPA Antagonist, SYM2206, Tocris Bioscience
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