SR 27897 | Peptides (Gastrointestinal) | Potent & Selective CCK1 Antagonist | Lintitript | SR27897

Category:

7TM Receptors

Peptides (Gastrointestinal)

CCK Receptors

Cat.No.

Product Name

2190

SR 27897

Alternative name(s):

Lintitript

SR 27897 C20H14ClN3O3S 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid

Price and Availability

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SR 27897

Chemical Name: 2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H- indole-1-acetic acid

Biological Activity:

Potent, non-peptide CCK₁ receptor antagonist that displays > 33-fold selectivity over CCK₂ receptors (EC₅₀ values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo.

Technical Data:

M.Wt:	411.86
Formula:	C₂₀H₁₄ClN₃O₃S
Storage:	Desiccate at +4°C
Solubility:	Soluble to 50 mM in DMSO
Purity:	>99%
CAS No:	[136381-85-6]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Gully et al (1993) Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors. Eur.J.Pharmacol. 23 232. Gouldson et al (1999) Contrasting roles of Leu³⁵⁶ in the human CCK₁ receptor for antagonist SR 27897 and agonist SR 146131 binding. Eur.J.Pharmacol. 383 339. Cano et al (2003) Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors. Br.J.Pharmacol. 140 647.

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Keywords: SR 27897, Peptides (Gastrointestinal), Potent & Selective CCK1 Antagonist, Lintitript, SR27897, Tocris Bioscience

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