SR 142948 | Peptides (Neuropeptides) | Highly Potent NT Receptor Antagonist | SR142948

Category:

Cat.No.	Product Name
2309	SR 142948

Price and Availability

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SR 142948

Chemical Name: 2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)p ropyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H -pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decan e-2-carboxylic acid

Biological Activity:

Potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC₅₀ = 0.32-3.96 nM). Orally active in vivo.

Technical Data:

M.Wt:	685.86
Formula:	C₃₉H₅₁N₅O₆
Storage:	Store at +4°C
Solubility:	Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Purity:	>97%
CAS No:	[184162-64-9]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Gully et al (1997) Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J.Pharmacol.Exp.Ther. 280 802. Quere et al (1998) X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist. Bioorg.Med.Chem.Lett. 8 653.

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Keywords: SR 142948, Peptides (Neuropeptides), Highly Potent NT Receptor Antagonist, SR142948, Tocris Bioscience

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