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Category:
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Cellular Processes and Components Signal TransductionCalcium SignallingGeneral Calcium Signalling Agents
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Cat.No.
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Product Name
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2184 |
SN-6
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Price and Availability
Click here for full price details of
SN-6
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Chemical Name:
2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazoli
dinecarboxylic acid ethyl ester |
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Biological Activity:
Selective Na+/Ca2+-exchange (NCX) inhibitor;
displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+
uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity
for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors
and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is
more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischaemic;
potently protects against hypoxia-induced renal tubular cell damage (IC50
= 0.63 μM).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Iwamoto et al (2004) The exchanger inhibitory peptide
region-dependent inhibition of Na+/Ca2+ exchange by SN-6
[2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a
novel benzyloxyphenyl derivative. Mol.Pharmacol. 66 45. Iwamoto
(2004) Forefront of Na+/Ca2+ exchanger studies: molecular
pharmacology of Na+/Ca2+ exchange inhibitors.
J.Pharmacol.Sci. 96 27.
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View related products by Pharmacological Action
or by Research Area
Keywords: SN-6, Signal Transduction, Selective Na+ / Ca2+ Exchange Inhibitor (reverse Mode), SN6, Tocris Bioscience
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Literature in this Area Scientific Reviews
Mechanisms for Manipulating Intracellular Calcium Buffering Download PDF Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
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