|
Category:
|
7TM Receptors Adrenergic ReceptorsAlpha-1 ReceptorsAntagonists
|
|
Cat.No.
|
Product Name
|
|
2398 |
SNAP 5089
|
|
|
|
Price and Availability
Click here for full price details of
SNAP 5089
|
|
Chemical Name:
5-[[[3-(4,4-Diphenyl-1-piperidinyl)propyl]amino]carbony
l]-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3-pyridin
ecarboxylic acid methyl ester hydrochloride |
|
|
Biological Activity:
Subtype selective α1A-adrenoceptor
antagonist that displays > 600-fold selectivity over other adrenoceptors (Ki
values are 0.35, 220, 370, 540, 800 and 1200 nM for α1A, α1B, α2C, α1D, α2B
and α2A
subtypes respectively and 540 nM for L-type Ca2+ channels). Inhibits
noradrenaline-induced contractions in rabbit vascular and lower urinary
tissues.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Wetzel et al
(1995) Discovery of α1a-adrenergic
receptor antagonists based on the L-type Ca2+ channel antagonist
niguldipine. J.Med.Chem. 38 1579. Leonardi et al
(1997) Pharmacological characterization of the uroselective alpha-1
antagonist Rec 15-2739 (SB 216469): role of the alpha-1L adrenoceptor in
tissue selectivity, Part I. J.Pharmacol.Exp.Ther. 281 1272. Kava
et al (1998) α1L-adrenceptor
mediation of smooth muscle contraction in rabbit bladder neck: a model for
lower urinary tract tissues of man. Br.J.Pharmacol. 123 1359.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: SNAP 5089, Adrenergic Receptors, Subtype Selective A1A-adrenoceptor Antagonist, Tocris Bioscience
|
|
|
