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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowAcetylcholine (Nicotinic) ReceptorsarrowOther Acetylcholine
Cat.No. Product Name
0751 SM-21 maleate  
Price and Availability

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SM-21 maleate
Chemical Name: (±)-Tropanyl 2-(4-chlorophenoxy)butanoate maleate

Biological Activity:

Potent and selective σ2 antagonist with central effects following systemic administration. Causes increased release of acetylcholine at central muscarinic synapses. Potent analgesic (efficacy comparable to morphine) and nootropic agent.

Technical Data:

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M.Wt: 453.92
Formula: C18H24ClNO3.C4H4O4
Storage: Store at RT
Solubility: Soluble to 25 mM in Water
CAS No: [155058-71-2]

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    References:

    Ghelardini et al (1997) Antinociceptive profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): a novel analgesic with a presynaptic cholinergic mechanism of action. J.Pharmacol.Exp.Ther. 282 430. Ghelardini et al (2000) Pharmacological identification of SM-21, the novel s2 antagonist. Pharmacol.Biochem.Behav. 67 659. Matsumoto and Mack (2001) (±)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice. Eur.J.Pharmacol. 417 R1.

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    Keywords: SM-21 Maleate, Ligand-gated Ion Channels, Presynaptic Cholinergic Modulator , SM21 Maleate, Tocris Bioscience
    Literature in this Area
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    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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