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Category: EnzymesarrowKinasesarrowMAPK/MAPKK
Cat.No. Product Name
2008 SKF 86002 dihydrochloride
Price and Availability

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SKF 86002
Chemical Name: 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2 ,1-b]thiazole dihydrochloride

Biological Activity:

Inhibitor of p38 MAP kinase (IC50 = 0.1-1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50 values are 10 and 100 μM respectively). Anti-inflammatory following oral administration in vivo.

Technical Data:

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M.Wt: 370.27
Formula: C16H12FN3S.2HCl
Storage: Desiccate at +4°C
Solubility: Soluble to 50 mM in Water
Purity: >98%
CAS No: [72873-74-6]

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    References:

    Griswold et al (1987) SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem.Pharmacol. 36 3463. Lee et al (1994) A protein kinase involved in the regulaton of inflammatory cytokine biosynthesis. Nature 372 739. Nick et al (1997) Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J.Clin.Invest. 99 975.
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    Keywords: SKF 86002, Kinases, P38 MAP Kinase Inhibitor; Anti-inflammatory Agent, SKF86002, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    Function & Modulation of MAP Kinase Pathways
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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