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Category:
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7TM Receptors Dopamine ReceptorsD1-like Receptors
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Cat.No.
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Product Name
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2074 |
SKF 83959 hydrobromide
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Price and Availability
Click here for full price details of
SKF 83959
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Chemical Name:
6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)
-1H-3-benzazepine-7,8-diol |
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Biological Activity:
Dopamine
D1-like receptor partial agonist (Ki values are 1.18,
7.56, 920 and 399 nM for rat D1, D5, D2 and D3
receptors respectively). May act as an antagonist in vivo, producing
anti-Parkinsonian effects and antagonising the behavioural effects of cocaine.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Platt et al (2000) Dissociation of
cocaine-antagonist properties and motoric effects of the D1 receptor partial
agonists SKF 83959 and SKF 77434. J.Pharmacol.Exp.Ther. 293 1017.
Cools et al (2002) SKF 83959 is an antagonist of dopamine D1-like
receptors in the prefrontal cortex and nucleus accumbens: a key to its
antiparkinsonian effect in animals? Neuropharmacology 42 237. Neumeyer
et al (2003) Receptor affinities of dopamine D1 receptor-selective
novel phenylbenzazepines. Eur.J.Pharmacol. 474 137.
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View related products by Pharmacological Action
or by Research Area
Keywords: SKF 83959, Dopamine Receptors, D1-like Partial Agonist, SKF83959, Tocris Bioscience
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